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Prognostic analysis of chronic myeloid leukemia in Chinese population in an imatinib era

null

《医学前沿（英文）》 2012年 第6卷 第2期   页码 204-211 doi: 10.1007/s11684-012-0202-x

摘要：

We evaluated the outcomes of chronic myeloid leukemia (CML) patients in three clinical phases, namely, chronic (CP), accelerated (AP), and blast (BP) phases, receiving imatinib treatment. The single-institution treatment experiences of Chinese patients with CML were presented. A total of 275 CML patients (CP, 210; AP, 24; and BP, 41) who received imatinib between February 2001 and April 2008 were enrolled in this study. We evaluated the responses (hematologic, cytogenetic, and molecular), overall survival (OS), treatment event-free survival (EFS), and prognostic factors of outcome. At the cut-off point, the complete cytogenetic response (CCyR) and complete molecular response rates of patients in the CP were 84.7% and 61.9%, respectively, which were significantly higher than those of patients in the AP (50% and 29.1%, respectively, both P<0.001) and BP (24.3% and 9.7%, respectively, both P<0.001). The estimated five-year OS and five-year EFS rates were 93.2% and 86.4% for CP patients, as well as 64.5% and 50.9% for AP patients, which were significantly higher than those for BP patients (P<0.001). In CP patients, univariate analysis revealed that early treatment with imatinib, achieving CCyR within 12 months, additional cytogenetic abnormalities, and kinase domain mutations were associated with the treatment outcome. More patients are needed to carry out multivariate analysis.

关键词： imatinib     chronic myeloid leukemia     complete cytogenetic response    

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Research progress and prospects of complete ammonia oxidizing bacteria in wastewater treatment

《环境科学与工程前沿（英文）》 2022年 第16卷 第9期 doi: 10.1007/s11783-022-1555-2

摘要：

• Comammox bacteria have unique physiological characteristics.

关键词： Complete ammonia oxidizing (comammox) bacteria     Nitrogen cycle     Physiological characteristics     Wastewater treatment    

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Integration of microbial reductive dehalogenation with persulfate activation and oxidation (Bio-RD-PAO) for complete

《环境科学与工程前沿（英文）》 2022年 第16卷 第2期 doi: 10.1007/s11783-021-1457-8

摘要：

•Bio-RD-PAO can effectively and extensively remove organohalides.

关键词： Bio-RD-PAO     Microbial reductive dehalogenation     Persulfate     Organohalide respiration     Complete attenuation    

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Complete oxidation of methane on CoO-SnO catalysts

Xingfu TANG , Jiming HAO , Junhua LI ,

《环境科学与工程前沿（英文）》 2009年 第3卷 第3期   页码 265-270 doi: 10.1007/s11783-009-0019-2

摘要： CoO-SnO hybrid oxides were prepared by the coprecipitation method and were used to oxidate methane (CH) in presence of oxygen. The CoO-SnO with a molar ratio of Co/(Co+Sn) at 0.75 exhibited the highest catalytic activity among all the CoO-SnO hybrid oxides. Experimental results showed that the catalysts were considerably stable in the CH combustion reaction, and were verified by X-ray photoelectron spectra (XPS). It was found that CoO was the active species, and SnO acted as a support or a promoting component in the CoO-SnO hybrid oxides. The surface area was not a major factor that affected catalytic activity. The hydrogen temperature-programmed reduction (H-TPR) results demonstrated that the interaction between cobalt and tin oxides accelerated the mobility of oxygen species of CoO-SnO, leading to higher catalytic activity.

关键词： Co3O4-SnO2     complete oxidation     methane (CH4)    

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Porous silica synthesis out of coal fly ash with no residue generation and complete silicon separation

《环境科学与工程前沿（英文）》 2023年 第17卷 第9期 doi: 10.1007/s11783-023-1712-2

摘要：

● Both amorphous and crystalline silicon are completely separated from coal fly ash.

关键词： Coal fly ash     Alkali fusion     Micro-/meso-porous Si     Zeolite MCM-48     Crystalline transformation    

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Synthesis of methanol and ethanol over CuZnAl slurry catalyst prepared by complete liquid-phase technology

Wei HUANG, Linmei YU, Wenhui LI, Zhili MA

《化学科学与工程前沿（英文）》 2010年 第4卷 第4期   页码 472-475 doi: 10.1007/s11705-010-0525-6

摘要： A new method, named the complete liquid-phase technology, has been applied to prepare catalysts for methanol synthesis. Its main innovative thought lies in preparing slurry catalysts directly from raw solution. Activity tests indicate that the CuZnAl slurry catalyst prepared by the new method can efficiently catalyze conversion of syngas to ethanol in a slurry reactor, while CO conversion reaches 35.9% and ethanol selectivity is more than 20%, with a total alcohol selectivity of more than 87%. No deactivation was found during the 192 h reaction .

关键词： methanol     slurry     ethanol     complete liquid-phase technology     CuZnAl catalyst    

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Existence of complete band gaps in 2D steel-water phononic crystal with square lattice

Cunfu HE, Huanyu ZHAO, Ruiju WEI, Bin WU

《机械工程前沿（英文）》 2010年 第5卷 第4期   页码 450-454 doi: 10.1007/s11465-010-0105-y

摘要： This paper theoretically and experimentally studies the existence of complete band gaps in two-dimensional (2D) phononic crystal consisting of parallel steel rods in water with square lattice. The band structure of phononic crystal is calculated by a plane wave expansion (PWE) method. Based on the well-known ultrasonic immersion transmission technique, the overlapping transmission spectra of acoustic waves, a complete band gap, is experimentally measured along the two high-symmetry directions of the first irreducible Brillouin zone. There is a very good agreement between the experimental result and the range of frequencies of the complete band gap.

关键词： phononic crystal     plane wave expansion (PWE) method     experimental study    

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Nanostructured gold films exhibiting almost complete absorption of light at visible wavelengths

Hanbin Zheng, Christine Picard, Serge Ravaine

《化学科学与工程前沿（英文）》 2018年 第12卷 第2期   页码 247-251 doi: 10.1007/s11705-018-1710-2

摘要： Nanostructured metal surfaces have been known to exhibit properties that deviate from that of the bulk material. By simply modifying the texture of a metal surface, various unique optical properties can be observed. In this paper, we present a simple two step electrochemical process combining electrodeposition and anodization to generate black gold surfaces. This process is simple, versatile and up-scalable for the production of large surfaces. The black gold films have remarkable optical behavior as they absorb more than 93% of incident light over the entire visible spectrum and also exhibit no specular reflectance. A careful analysis by scanning electron microscopy reveals that these unique optical properties are due to their randomly rough surface, as they consist in a forest of dendritic microstructures with a nanoscale roughness. This new type of black films can be fabricated to a large variety of substrates, turning them to super absorbers with potential applications in photovoltaic solar cells or highly sensitive detectors and so on.

关键词： nanostructuration     light absorption     coating     gold     electrodeposition     anodization    

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自然流产的细胞遗传学研究进展

罗岚蓉,李坚

《中国工程科学》 2015年 第17卷 第6期   页码 65-69

摘要：

自然流产是妊娠并发症，指妊娠在28周之前自然终止，其发病率在15 %～40 %。近年来在辅助生育技术的使用中，同样面临着较高的自然流产率的问题。自然流产的病因十分复杂，除了遗传因素以外，还包括解剖因素、内分泌因素、感染因素、环境因素、免疫因素、血栓前状态以及母体的全身性疾病等等。自然流产的细胞遗传学研究，主要在两个方面，一是胚胎染色体的异常，包括染色体数量异常和结构异常；二是夫妇染色体的异常。在自然流产中胚胎染色体异常的检出率在60 %左右，且随着流产次数的增加，染色体异常的比例下降。其中大部分为胚胎染色体数目异常如三体、三倍体及X单体等，较少为染色体结构异常，包括染色体断裂、倒置、缺失和易位等。在自然流产的夫妇中，尤其是反复自然流产的夫妇，其染色体异常的检出率在8 %左右，且随着流产次数的增加异常的比例升高。成人染色体的异常多为染色体的平衡易位。随着细胞遗传学的检测技术的发展，从传统染色体核型分析和荧光原位杂交技术到染色体微阵列芯片分析、第二代测序技术即高通量测序技术的相继应用，使得自然流产的遗传学方面的研究更加深入。自然流产的细胞遗传学的研究进展，对于自然流产的病因研究以及生育指导有着非常重要的意义。

关键词： 自然流产     细胞遗传学     染色体异常    

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薄煤层刨煤机成套装备关键技术研究

宋秋爽

《中国工程科学》 2011年 第13卷 第11期   页码 33-38

摘要：

针对薄煤层安全、经济开采这一世界性难题，分析我国薄煤层资源分布以及开采技术现状，提出我国刨煤机成套装备系统所存在的技术问题，通过对成套装备关键技术的分析及研究，提出技术解决方法和途径，为刨煤机的自动化工作面提供技术支持。

关键词： 刨煤机成套装备     定向定量推移     异构地质     自适应控制    

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A complete modeling and simulation of DFIG based wind turbine system using fuzzy logic control

Abdelhak DIDA,Djilani BENATTOUS

《能源前沿（英文）》 2016年 第10卷 第2期   页码 143-154 doi: 10.1007/s11708-016-0402-1

摘要： The current paper talks about the variable speed wind turbine generation system (WTGS). So, the WTGS is equipped with a doubly-fed induction generator (DFIG) and two bidirectional converters in the rotor open circuit. A vector control (VC) of the rotor side converter (RSC) offers independent regulation of the stator active and reactive power and the optimal rotational speed tracking in the power maximization operating mode. A VC scheme for the grid-side converter (GSC) allows an independent regulation of the active and reactive power to exchange with the grid and sinusoidal supply currents and keeps the DC-link voltage constant. A fuzzy inference system (FIS) is adopted as an alternative of the conventional proportional and integral (PI) controller to reject some uncertainties or disturbance. The performances have been verified using the Matlab/Simulink software.

关键词： wind turbine generation system (WTGS)     doubly-fed induction generator (DFIG)     maximum power point tracking (MPPT)     vector control (VC)     fuzzy logic controller (FLC)    

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全新产品的创意生成方法分析

师爱芬,谢建华

《中国工程科学》 2002年 第4卷 第11期   页码 89-93

摘要：

从社会和顾客的需要入手，研究了全新产品创意的生成技术及流程图，并分析了“会飞的机器”的创意生成方法和过程，探索了全新产品创意生成的内在规律性。文章首先确定所要构思“产品”的主要特征,再依据物元的蕴含性找到根本特征，进一步寻找具备这些特征的事物和量值。根据事物、特征、量值之间的相依关系按照一定的原理进行组合得出一个系统集合，对这个系统集合进行修整、完善、优化，得出全新产品创意集合。

关键词： 全新产品     创意     物元     物元的蕴含性    

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Research on Microelectromagnetic Relays

LI De-sheng, LIU Ben-dong

《机械工程前沿（英文）》 2006年 第1卷 第1期   页码 111-114 doi: 10.1007/s11465-005-0013-8

摘要：

A new microelectromagnetic relay is presented and fabricated based on micromachining technology, aiming at the miniaturization and high manufacturing efficiency of electromagnetic relays. This microrelay is composed of a lower magnetic circuit, a planar exciting coil, and an upper magnetic armature. A complete magnetic circuit is composed, and the ON and OFF states are controlled by the current of the exciting coil. The dimension of this microrelay is 5 mm ? 5 mm ? 0.4 mm. The fabrication process mainly includes lithography, sputtering, electroplating, etching, sacrifice-layer technology, etc. Electromagnetic force is calculated theoretically. The calculation results are used for the optimization design of the armature and the number of turns of the exciting coil. A microelectromagnetic relay is fabricated and the initial test results are given. The resistance of the exciting coil is about 300 Ω. The switch-on state resistance is about 1.7 Ω at an exciting current of about 50 mA.

关键词： sacrifice-layer technology     OFF     complete     microelectromagnetic     Electromagnetic    

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Venetoclax and low-dose cytarabine induced complete remission in a patient with high-risk acute myeloid

Bingshan Liu, Roshni Narurkar, Madhura Hanmantgad, Wahib Zafar, Yongping Song, Delong Liu

《医学前沿（英文）》 2018年 第12卷 第5期   页码 593-599 doi: 10.1007/s11684-018-0635-y

摘要：

Conventional combination therapies have not resulted in considerable progress in the treatment of acute myeloid leukemia (AML). Elderly patients with AML and poor risk factors have grave prognosis. Midostaurin has been recently approved for the treatment of FLT-3-mutated AML. Venetoclax, a BCL-2 inhibitor, has been approved for the treatment of relapsed and/or refractory chronic lymphoid leukemia. Clinical trials on applying venetoclax in combination with cytarabine and other agents to treat various hematological malignancies are currently underway. Here, we present a case of a male patient with poor performance status and who developed AML following allogeneic hematopoietic stem cell transplant for high-risk myelodysplasia. The patient with high risk AML achieved complete response to the combined treatment regimen of low-dose cytarabine and venetoclax. Furthermore, we reviewed current clinical trials on the use of venetoclax for hematological malignancies.

关键词： venetoclax     cytarabine     AML     leukemia    

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Development of a seismic design method based on response spectra for building structures

ZHOU Xiyuan, YU Ruifang

《结构与土木工程前沿（英文）》 2007年 第1卷 第2期   页码 129-141 doi: 10.1007/s11709-007-0014-2

摘要： The assumption and problem of the mode-superposition response spectrum method in seismic design code is discussed based on a brief review of the development of the seismic design method for building structures. The scope of application for the classical damping theory is analyzed and the necessity of the research on mode-superposition method for non-classical damping is presented. The progresses on the mode superposition response spectrum theory are discussed. This includes: 1) the complex mode superposition method (in real form) for the non-classically damped linear system and the general calculation formula for the application of code; 2) the complex complete quadratic combination (CCQC) method for the non-classically damped linear system, which is based on the same assumptions as in deducing the complete quadratic combination (CQC) method which is popularly used in seismic design codes of many countries; 3) the complex complete quadratic combination with three components (CCQC3) method, which is a generalization of the CCQC method to the case of multi-components and multiple-support seismic excitations and deducing corresponding method; 4) the approach for calculation of seismic response of the non-classically damped system with overcritical damping and the calculation method of seismic response for the linear system with multiple eigenvalues; 5) the time-dependent CCQC (t) algorithm considering nonstationary earthquake ground motion; 6) an applied and effective method to solve the low order complex vector basis for the large linear non-classically damped system, which can be expediently used in practice to avoid the unknown errors coming from the forced uncoupling method; 7) bringing forward the concept of partial quadratic combination in order to reduce the calculation amount of CQC and CCQC methods, and studying the primary estimation-criterion. The reasonability and applicable scope of these methods are also briefly discussed in this paper.

关键词： generalization     classical damping     mode-superposition response     calculation formula     damping theory    

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标题 作者 时间 类型 操作

Prognostic analysis of chronic myeloid leukemia in Chinese population in an imatinib era

null

期刊论文

Research progress and prospects of complete ammonia oxidizing bacteria in wastewater treatment

期刊论文

Integration of microbial reductive dehalogenation with persulfate activation and oxidation (Bio-RD-PAO) for complete

期刊论文

Complete oxidation of methane on CoO-SnO catalysts

Xingfu TANG , Jiming HAO , Junhua LI ,

期刊论文

Porous silica synthesis out of coal fly ash with no residue generation and complete silicon separation

期刊论文

Synthesis of methanol and ethanol over CuZnAl slurry catalyst prepared by complete liquid-phase technology

Wei HUANG, Linmei YU, Wenhui LI, Zhili MA

期刊论文

Existence of complete band gaps in 2D steel-water phononic crystal with square lattice

Cunfu HE, Huanyu ZHAO, Ruiju WEI, Bin WU

期刊论文

Nanostructured gold films exhibiting almost complete absorption of light at visible wavelengths

Hanbin Zheng, Christine Picard, Serge Ravaine

期刊论文

自然流产的细胞遗传学研究进展

罗岚蓉,李坚

期刊论文

薄煤层刨煤机成套装备关键技术研究

宋秋爽

期刊论文

A complete modeling and simulation of DFIG based wind turbine system using fuzzy logic control

Abdelhak DIDA,Djilani BENATTOUS

期刊论文

全新产品的创意生成方法分析

师爱芬,谢建华

期刊论文

Research on Microelectromagnetic Relays

LI De-sheng, LIU Ben-dong

期刊论文

Venetoclax and low-dose cytarabine induced complete remission in a patient with high-risk acute myeloid

Bingshan Liu, Roshni Narurkar, Madhura Hanmantgad, Wahib Zafar, Yongping Song, Delong Liu

期刊论文

Development of a seismic design method based on response spectra for building structures

ZHOU Xiyuan, YU Ruifang

期刊论文